Viral cancers: AIDS virus at the center

Non-AIDS defining cancers.

MEDICINE & HEALTH/RHODE ISLAND Reductions in HIV-associated morbidity and mortality in the era of highly active antiretroviral therapy (HAART) have been accompanied by increases in the incidence of some malignancies in people with HIV/ AIDS. Indeed, malignancy is now one of the most frequent causes of death and leading cause of hospitalizations in HIV-infected people in the HAART era. The World...

Non–AIDS-Defining Cancers

HIV-infected individuals are living longer as a result of more effective and better tolerated antiretroviral treatment and fewer risks of opportunistic diseases. The overall incidence of AIDS-defining cancers (ADCs) among HIV-infected individuals has decreased, reflecting lower rates of such cancers as Kaposi sarcoma and non-Hodgkin lymphoma (NHL) in patients aged 40 years or younger. Concurren...

Rapalogs in viral cancers.

At present, 150 clinical trials are registered with the National Cancer Institute, which investigate the efficacy of inhibitors of the PI3K/Akt/mTOR pathway against multiple cancers. Efficacy varies not so much with drug action, but with tumor type, as different cancer types (and different pre-clinical models) exhibit widely differing susceptibilities to mTOR inhibitors, such as rapamycin. Vira...

The viral etiology of AIDS-associated malignancies.

Persistent bovine viral diarrhea virus (BVDV) infection in cattle herds

Bovine viral diarrhea virus (BVDV) is a significant pathogen associated with gastrointestinal, respiratory, and reproductive diseases of cattle worldwide. It causes continuous economic losses to the cattle industry primarily due to decreased reproductive performance. The ability of virus to cross the placenta during early pregnancy can result in the birth of persistently infected (PI) calves. P...